The associations between physical activity intensity, cardiorespiratory fitness, and non-alcoholic fatty liver disease.

Kerr, Catherine J, Waterworth, Sally P, Brodie, David, Sandercock, Gavin R H and Ingle, Lee (2021) The associations between physical activity intensity, cardiorespiratory fitness, and non-alcoholic fatty liver disease. Journal of Gastroenterology and Hepatology. ISSN 1440-1746

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Abstract

High levels of physical activity and cardiorespiratory fitness may protect against non-alcoholic fatty liver disease. We investigated whether different physical activity intensities and cardiorespiratory fitness were independent predictors of non-alcoholic fatty liver disease. We included healthy adults with no prior diagnosis of liver dysfunction. Non-alcoholic fatty liver disease prevalence was estimated based on fatty liver index scores. We created tertiles of self-reported low, moderate, and vigorous physical activity. Participants completed an incremental treadmill test to estimate cardiorespiratory fitness, and data were subsequently separated into quintile groups (Q1 [least fit] through Q5 [most fit]). Non-alcoholic fatty liver disease prevalence in our sample of 7111 adults was 28.3% in male adults and 6.5% in female adults. Logistic regression showed the relative odds of non-alcoholic fatty liver disease were 42% lower if > 60 min/week of vigorous physical activity was maintained (odds ratio [OR] = 0.58, confidence interval [CI]: 0.49-0.68). There was a negative dose-response association between cardiorespiratory fitness and non-alcoholic fatty liver disease between Q1 and Q4. Compared with Q1, odds were 39% (OR = 0.61, CI: 0.51-0.73) lower in Q2, through to 51% lower in Q5 (OR = 0.49, CI: 0.41-0.60). Moderate physical activity did not reduce the odds of non-alcoholic liver disease. We found the lowest prevalence of non-alcoholic fatty liver disease in adults achieving > 60 min/week of vigorous physical activity. However, a stronger dose-response relationship existed between cardiorespiratory fitness and non-alcoholic fatty liver disease. Improving cardiorespiratory fitness as a potential therapeutic target for treatment and prevention of non-alcoholic fatty liver disease warrants further investigation. [Abstract copyright: © 2021 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.]

Item Type:	Article
Additional Information:	** From PubMed via Jisc Publications Router ** History: received 04-01-2021; revised 28-07-2021; accepted 20-08-2021.
Keywords:	Fatty liver, Cardiorespiratory fitness, Physical exertion, Physical activity
SWORD Depositor:	JISC Router
Depositing User:	JISC Router
Date Deposited:	20 Sep 2021 09:03
Last Modified:	20 Sep 2021 09:03
URI:	https://bnu.repository.guildhe.ac.uk/id/eprint/18431

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