How do physiological ageing and frailty affect human body systems?

Alsararatee, Hasan H (2025) How do physiological ageing and frailty affect human body systems? Journal of Prescribing Practice, 7 (9). pp. 382-389. ISSN 2631-8393

Text 20642_Alsararatee.pdf - Accepted Version Restricted to Repository staff only until 3 March 2026. Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (376kB) | Request a copy

Abstract

Physiological ageing leads to a progressive decline in the functional reserve of multiple organ systems, contributing to the development of frailty, a multidimensional syndrome observed by increased vulnerability to stressors and adverse health outcomes in older adults. This article explores the physiological changes across various systems, including neurological, cardiovascular, respiratory, genitourinary, gastrointestinal, endocrine, integumentary, musculoskeletal and haematological domains, and explores how these changes underpin the clinical features of frailty. By differentiating age-related decline from pathological processes, the review emphasises the importance of system specific knowledge in guiding individualised assessment, prevention and care. Understanding these correlated mechanisms is essential for healthcare professionals managing the complexities of frailty in ageing populations.

Item Type:	Article
Additional Information:	** From Crossref journal articles via Jisc Publications Router ** History: ppub 02-09-2025; issued 02-09-2025.
SWORD Depositor:	JISC Router
Depositing User:	JISC Router
Date Deposited:	02 Oct 2025 10:32
Last Modified:	23 Oct 2025 13:54
URI:	https://bnu.repository.guildhe.ac.uk/id/eprint/20642

Actions (login required)

Edit Item